newz
goodpizza.com.au
BENZODIAZEPINES ANDBUPRENORPHINE
Online DoctorReview
Best Online DoctorReview
https://bestonlinedoctors.com.au/
Disclosure of Relevant Financial Relationships Content ofActivity:
PCSS-O Buprenorphine/BenzodiazepinePresentation
Name
Stephen A.Wyatt,DO
Com merc ial Inter ests
Relevant Financial Relationships: What Was Received
Relevant Financial Relationships: For WhatRole
No Relevant Financial Relationships with Any Commercial Interests
None
X
Best Online DoctorReview
WHY ARE WE TALKING ABOUTTHEM?
Best Online DoctorReview
"BLUELIGHT"
OnlineDoctorReviewBest Online DoctorReview
TREATMENTADMISSIONS
Online DoctorReview
https://bestonlinedoctors.com.au/
Best Online DoctorReview
EPIDEMIOLOGY OFBENZODIAZEPINES
https://bestonlinedoctors.com.au/
Online DoctorReview
Best Online DoctorReview
EPIDEMIOLOGY
XANAX
OnlineDoctorReviewBest Online DoctorReview
EPIDEMIOLOGY
Online DoctorReview
Best Online DoctorReview
EPIDEMIOLOGY OFBENZODIAZEPINES
OnlineDoctorReviewBest Online DoctorReview
SEDATIVEHYPNOTICS
Online DoctorReview
Best Online DoctorReview
MECHANISM OF ACTION -GABAARECEPTOR
https://bestonlinedoctors.com.au/
MECHANISM OF ACTION -GABAARECEPTOR
.
GABAA receptor is the binding site forGABA
.
Differentallostericbinding sites modulate theactivity.
Directagonists
.
Enhanced GABAbinding
.
The allosteric sites are the targets of variousdrugs,
ethanol
neuroactivesteroids, inhaledanaesthetics
Online DoctorReview
Best Online DoctorReview
PHARMACOKINETICSBENZODIAZEPINES
Online DoctorReview
Best Online DoctorReview
COGNITION
OnlineDoctorReviewBest Online DoctorReview
MOST ABUSEDBENZODIAZEPINES
Online DoctorReview
Best Online DoctorReview
ONBLINE DOECTORRNEVIEWZODIAZEPINEUSE PATTERNS
.
Recreational abuse of BZs alone isuncommon
�Commonly taken as part of polysubstanceabuse
.
Motivations.
Euphoria
.
Augment euphoriant effect of other drugs, especiallyopiates
.
Up to 80% of opiate abusers have takenBZs
.
To ease the "crash" fromcocaine
.
29%-33% of alcohol abusers takeBZs
BenzodiazepineDependence,Toxicity,andAbuse:ATaskForceReportoftheAmerican PsychiatricAssociation.Washington,DC,APA,1990
BENZODIAZEPINEABUSE
Best Online DoctorReview
STREETMARKET
Online DoctorReview
Best Online DoctorReview
HOW REINFORCING AREBENZODIAZEPINES?
Online DoctorReview
Best Online DoctorReview
PHARMACOKINETICSBENZODIAZEPINES
Online DoctorReview
Best Online DoctorReview
Online DoctorReview
Addiction (1998) 93(9),1385�1392
Best Online DoctorReview
PHARMACODYNAMICS -ANIMALMODEL
OnlineDoctorReviewBest Online DoctorReview
PHARMACODYNAMICS -ANIMALMODEL
OnlineDoctorReviewBest Online DoctorReview
EPIDEOMNLINE DIOOCTORLREOVIEWGYOF:
Buprenorphine andBenzodiazepines
Best Online DoctorReview
EPIDEMIOLOGYOF:
BUPRENORPHINE ANDBENZODIAZEPINES
Online DoctorReview
Best Online DoctorReview
PHARMACODYNAMICS
Online DoctorReview
Best Online DoctorReview
PHARMACODYNAMICS
Online DoctorReview
Best Online DoctorReview
BENZODIAZAPINE PLUS: BUPRENORPHINE VS.METHADONE
Online DoctorReview
Best Online DoctorReview
BENZODIAZAPINEPLUS:
OnlineDoctorReviewBest Online DoctorReview
ONCLINE DOOCTORRMEVIEW BINEDBENZODIAZEPINESANDBEST ONLINE DOCTORREVIEW
Buprenorphine
.
Cohort study of 325 buprenorphine with past year benzodiazepine use andmisuse.
.
Not associated with treatment retention or illicit opioid use (urine toxicologyscreens)
.
No greater overdoserate.
.
Greater accidental injury related ED visits(>females)
ZSchuman-Olivier,et.al.,DrugandAlcoholDependence,October2013
WITHDRAWAL
Online DoctorReview
Best Online DoctorReview
BENZODIAZEPINE -WITHDRAWALTREATMENT
Online DoctorReview
Best Online DoctorReview
PROLONGEDWITHDRAWAL
Online DoctorReview
Best Online DoctorReview
ANTIDEPRESSANTS FORGAD
Kapczinski F, et al. Cochrane Database Syst Rev.2003;(2):CD003592.
Online DoctorReview
Best Online DoctorReview
TCAS FORANXIETY
Online DoctorReview
Best Online DoctorReview
AN APPROACH TO TALKING TO PATIENTS ABOUT ANXIETY.
OnlineDoctorReviewBest Online DoctorReview
AN APPROACH TO TALKING TO PATIENTS ABOUT PANIC.
.
Usemuch of the same approach as in the anxiouspatient.
.
Talk to them about the importance of notpanicking!
.
Explain the experience of of panic and the physiology hyperventilation..
SOB
.
Numbness and tingling of mouth andfingers
.
Upsetstomach
.
Chest heaviness
.
Visualabnormalities
.
Fainting
SUMMARY
OnlineDoctorReviewBest Online DoctorReview
By newz
Diazepam and clonazepam ≈ $2.00-$4.00/pill Many who seek these drugs for a "high" quickly move on to other agents High risk for continued misuse of BZs: Heroin dependent / methadone or buprenorphinemaintenance 75%+ admitted taking BZs to enhance intoxication or treatwithdrawal